TNF binders

专利名称：TNF binders

发明人：Marie-Ange Buyse,Joachim Boucneau,Peter

Casteels,Gino Van Heeke

申请号：US15501011申请日：20161114公开号：US10544211B2公开日：20200128

摘要：The present invention relates to amino acid sequences, compounds andpolypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). Inparticular, the present invention relates to improved heavy-chain immunoglobulin singlevariable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumornecrosis factor alpha, as well as to proteins, polypeptides and other constructs,compounds, molecules or chemical entities that comprise such ISVDs, collectively TNFbinders. Other aspects, embodiments, features, uses and advantages of the invention willbe clear to the skilled person based on the disclosure herein.

申请人：Ablynx N.V.

地址：Zwijnaarde BE

国籍：BE

代理机构：Wolf, Greenfield & Sacks, P.C.

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