Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Laquinimod248281-84-7HY-13010356.80C19H17ClN2O3>98%Solubility:DMSO ≥60 mg/mLMechanisms: Pathways:Others; Target:Others gyBiological Activity:Laquinimod (ABR-215062) is a potent immunomodulator. Laquinimod is a novel oral drug that iscurrently being evaluated for the treatment of relapsing-remitting (RR) multiple sclerosis (MS). Laquinimod has demonstrated significant activity in suppressing experimental autoimmuneencephalomyelitis, an animal model of RRMS. In phase I and II clinical trials, the drug was welltolerated, with some hints of efficacy in small numbers of patients with RRMS. While the mechanismof action of the drug is unknown, it likely involves Th1 to Th2/Th3 immune deviation, promotion ofthe synthesis and release of neurotrophic factors, and other possible neuroprotective effects. APhase II study of Laquinimod in active lupus arthritis patients is currently ongoing, if successful, willyqppygglead to the approval of the first oral immunomodulatory drug for suppressing multiple sclerosisdisease ac...References:[1]. Brueck, Wolfgang; Zamvil, Scott S. Laquinimod, a once-daily oral drug in development for thetreatment of relapsing-remitting multiple sclerosis. Expert Review of Clinical Pharmacology (2012),5(3), 245-256. [2]. Schulze-Topphoff, Ulf; Shetty, Aparna; Varrin-Doyer, Michel et al. Laquinimod, a quinoline-3-[]ppypyqqcarboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.PLoS One (2012), 7(3), e33797. [3]. Toubi E, Nussbaum S, Staun-Ram E et al. Laquinimod modulates B cells and their regulatoryeffects on T cells in Multiple Sclerosis. J Neuroimmunol. 2012 Oct 15;251(1-2):45-54. [4]. Th?ne J, Gold R. Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):365-70. [5]. Tselis A. Laquinimod, a new oral autoimmune modulator for the treat...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
